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Literature

Table of Contents

CURODONT™ REPAIR

(A) Original research – Clinical trials
  1. Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH. Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel. J Dent Res. 2018;97:148-154.
  2. Atteya SM, Amer HA, Saleh SM, Safwat Y. Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial. BMC Oral Health. 2023;23:577.
  3. Atteya SM, Amer HA, Saleh SM, Safwat Y. The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial. Clin Oral Investig. 2024 Feb 23;28:167.
  4. Aziz FA, Marei TH, Elmalt MA. Assessment of self-assembling peptide P 11-4 in the treatment of white spot lesions after orthodontic treatment. Egyptian Orthodontic Journal. 2016;50:35-48.
  5. Bröseler F, Tietmann C, Bommer C, Drechsel T, Heinzel-Gutenbrunner M, Jepsen S. Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries. Clin Oral Investig. 2020;24:123-132.
  6. Brunton PA, Davies RP, Burke JL, Smith A, Aggeli A, Brookes SJ, Kirkham J. Treatment of early caries lesions using biomimetic self-assembling peptides–a clinical safety trial. Br Dent J. 2013;215:E6.
  7. Godenzi D, Bommer C, Heinzel-Gutenbrunner M, Horst Keeper J, Peters K. Remineralizing potential of the biomimetic P11-4 self-assembling peptide on noncavitated caries lesions: A retrospective cohort study evaluating semistandardized before-and-after radiographs. J Am Dent Assoc. 2023:S0002-8177(23)00416-6.
  8. Gohar RAAEG, Ibrahim SH, Safwat OM. Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial. Clin Oral Investig. 2023;27:613-624.
  9. Kahm RA, Niazy MA, El-Yasaky MA. Clinical Performance and Remineralization Potential of Different Biomimitic Materials on White Spot Lesions. Al-Azhar Dental Journal for Girls, 2018;5:349-358.
  10. Kobeissi R, Badr SB, Osman E. Effectiveness of Self-assembling Peptide P11-4 Compared to Tricalcium Phosphate Fluoride Varnish in Remineralization of White Spot Lesions: A Clinical Randomized Trial. Int J Clin Pediatr Dent. 2020;13:451-456.
  11. Mamdouh C, Dowidar KM, Soliman RS. Effectiveness of self-assembling peptide (P11-4) in conjunction with fluoride varnish in the management of white spot lesions in primary teeth (randomized controlled clinical trial). Alexandria Dent J. 2023;47:37.
  12. Natchiyar N, Asokan S, Priya GP, Viswanath S. Comparison of Remineralizing Agents in the Management of White Spot Lesions In Three- to Five-year-old Children: a Clinical Trial. Pediatr Dent. 2023;45:99-106.
  13. Riad MF, Raafat R, Nabil Amin AM. Comparative Study Using Biomimetic Remineralization Versus Fluoride Varnish in Management of White Spot Lesion in Post Orthodontic Treated Patient: Split Mouth Randomized Clinical Trial. Ind J Pub Health Res Dev 2020;11:646-52.
  14. Schlee M, Schad T, Koch JH, Cattin PC, Rathe F. Clinical performance of self-assembling peptide P11 -4 in the treatment of initial proximal carious lesions: A practice-based case series. J Investig Clin Dent. 2018 Feb;9(1).
  15. Schlee, M., Rathe, F., Huck, T. et al. Klinischer Effekt biomimetischer Mineralisation bei Approximalkaries. Stomatologie 2014;111:175–181.
  16. Sedlakova Kondelova P, Mannaa A, Bommer C, Abdelaziz M, Daeniker L, di Bella E, Krejci I. Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial. Sci Rep. 2020;10:20211.
  17. Singh SK, Rathore M, Goyal A. Assesment of Remineralization of Hypomineralized Enamel Lesions Using Self-Assembling Peptide Using Laser Fluorescence- A Pilot Study. Saudi J Oral Dent Res 2021;6:498-501.
  18. Welk A, Ratzmann A, Reich M, Krey KF, Schwahn C. Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions. Sci Rep. 2020;10:6819.
(B) Original research – clinical trials testing Curodont Repair + Curodont Protect
  1. Doberdoli D, Bommer C, Begzati A, Haliti F, Heinzel-Gutenbrunner M, Juric H. Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Sci Rep. 2020;10:4195.
(C) Original trials – In vitro studies
  1. Abdullah Kamran M. Remineralization of eroded enamel for improved orthodontic bracket bonding: An in vitro study. Korean J Orthod. 2025 Jul 25;55(4):244-253.
  2. Aşık A, Önçağ Ö. Evaluation of the effect of self-assembling peptide and fluoride varnish, alone or in combination with laser irradiation, on artificial enamel caries: a SEM/EDS and Micro-CT study. Clin Oral Investig. 2024;28:503.
  3. Aşık A, Çoğulu D, Aykut Yetkiner A, Ersin N. Comparative evaluation of remineralization agents in severe enamel hypomineralization using a porcine enamel model. BMC Oral Health. 2026 Jun 29.
  4. Alsamolly, W. Comparative Assessment of remineralizing potential of recent biomimetic remineralizing agents on sub-surface carious lesions: An in vitro study. Egyptian Dental Journal 2021;67: 1711-1722.
  5. Alnazeh AA, Kamran MA, Alshehri A, Awadh W. Orthodontic Bracket bonded to Enamel pretreated with Er, Cr: YSGG, silver diamine fluoride and Self-Assembling Peptide P11-4. A Lab-based, SEM Assessment. Pak J Med Sci. 2025;41:3164-3168.
  6. Barbosa-Martins LF, de Sousa JP, de Castilho ARF, Puppin-Rontani J, Davies RPW, Puppin-Rontani RM. Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents. J Mech Behav Biomed Mater. 2018;81:214-221.
  7. Barbosa-Martins LF, Sousa JP, Alves LA, Davies RPW, Puppin-Rontanti RM. Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin. Materials (Basel). 2018;11:1733.
  8. Babaji P, Melkundi M, Bhagwat P, Mehta V. An in vitro Evaluation of remineralizing capacity of self-assembling peptide (SAP) P11-4 and casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) on artificial enamel. Pesquisa Brasileira em Odontopediatria e Clínica Integrada. 2019;19:e4504.
  9. Bakry AS, Alanazi AM, Alsulaimani FF, Abbassy MA. In-vitro comparative study for three different strategies to treat enamel demineralized white spot lesion. J Dent. 2025 May;156:105698.
  10. Bhargavi H, Naik SB, Kumar NK, Merwade S, Brigit B, Bhumralkar SS, Kadam AS, Preetham HS. Comparative Evaluation between Self-Assembling Peptide P11-4 and ACP CPP in Enamel Remineralization Post Er: YAG Laser Irradiation – A Confocal Laser Scanning Microscopic Study. Contemp Clin Dent. 2025;16:3-9.
  11. Deyhle H, Dziadowiec I, Kind L, Thalmann P, Schulz G, Müller B. Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach. Dent J 2015;3:111-122.
  12. Diaa El Din Abou El Seoud A, Naguib EAH, Abou Auf EA, Younis SH. Evaluation of the effect of two biomimetic approaches on micro-tensile bond strength of one etch & rinse adhesive to dentin (An in vitro study). Front Dent Med. 2026 Apr 8;7:1791403.
  13. Elewa SS, Elzainy MA, Hussein SI. The effect of self-assembling peptides versus sodium fluoride varnish on artificially induced enamel lesions in human premolars: in vitro study (scanning electron microscope and energy dispersive X-ray analysis). Egypt Dent J. 2023;69:2793–2805.
  14. Elwazir A, Fahmy O, Nabih S. Effect of Sodium Hypochlorite (NaOCl) for Pretreatment of Early Demineralized Enamel Lesions in Enhancing the Remineralization Capacity of Self-assembling Peptide (In-vitro Study). J Fund Clin Res 2012;1: 1-16.
  15. Fathima F, Shetty H. Evaluation of the Effect of Self Assembling Peptide-Curodont on Microhardness of Bleached Enamel Surface: An In Vitro Study. IOSR J Dent Medical Sci 2020;19:51-54.
  16. Hany K, Enany NM, Ahmed R. Elkalza AR. Evaluation of the efficacy of regenamel® in the tretment of white spot lesions (an in vitro study). Egypt Orth J 2019:56:21-29.
  17. Jablonski-Momeni A, Heinzel-Gutenbrunner M. Efficacy of the “Self-assembling peptide P11-4” in the formation of a remineralization scaffold on artificially induced enamel lesions on smooth surfaces.” J Orofac Orthop 2014;75:175-190.
  18. Jablonski-Momeni A, Nothelfer R, Morawietz M, Kiesow A, Korbmacher-Steiner H. Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets. Sci Rep. 2020;10:15132.
  19. Kamal D, Hassanein H, Elkassas D, Hamza H. Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An in vitro study. J Conserv Dent. 2018;21:536-541.
  20. Kamal D, Hassanein H, Elkassas D, Hamza H. Complementary remineralizing effect of self-assembling peptide (P11-4) with CPP-ACPF or fluoride: An in vitro study. J Clin Exp Dent. 2020;12:e161-e168.
  21. Klimaitė G, Vasiliauskas A, Grinkevičius P, Grinkevičienė D, Šapalas D. The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study. Medicina (Kaunas). 2025;61:462.
  22. Knaup T, Korbmacher-Steiner H, Jablonski-Momeni A. Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets. J Orofac Orthop. 2021;82:329-336.
  23. Krishnamoorthi A, Shanbhog RS, Godhi BS, Sundaravadivelu M. Efficacy of Self-assembling Peptide P11-4 in Remineralizing In Vitro Caries-like Lesions in Primary Enamel Samples in Combination with Calcium Phosphate-based Remineralization Agents. Int J Clin Pediatr Dent. 2024;17:552-557.
  24. Kucukyilmaz E, Savas S. Measuring the remineralization potential of different agents with quantitative light-induced fluorescence digital Biluminator. J Appl Biomater Funct Mater. 2017;15:e101-e106.
  25. Moreira KM, Bertassoni LE, Davies RP, Joia F, Höfling JF, Nascimento FD, Puppin-Rontani RM. Impact of biomineralization on resin/biomineralized dentin bond longevity in a minimally invasive approach: An “in vitro” 18-month follow-up. Dent Mater. 2021;37:e276-e289.
  26. Mousa E, Abdel-Fattah WM, Afifi RR. Surface microhardness of bleached teeth enamel following different remineralizing approaches (in-vitro study). Alexandria Dental Journal 2023;48:139-145.
  27. Nath SJC, Fu Y, Li KC, Loho T, Loch C, Ekambaram M. A Comparison of the Enamel Remineralisation Potential of Self-Assembling Peptides. Int Dent J. 2023:S0020-6539(23)00123-5.
  28. Özdemir Ş, Taran PK, Mammadlı N, Altınova İS, Gazioğlu I. Remineralization potential of P11-4 and fluoride on secondary carious primary enamel: A quantitative evaluation using microcomputed tomography. Microsc Res Tech. 2022;85:807-812.
  29. Pawar R, Samuel RM, Zinge P, Bhatt AP, Purohit S. Comparative Evaluation of the Shear Bond Strength of Composite to Remineralized Dentin: An In Vitro Study. Cureus. 2025;17:e92118.
  30. Savas S, Kucukyilmaz E, Celik EU. Effects of Remineralization Agents on Artificial Carious Lesions. Pediatr Dent. 2016;38:511-518.
  31. Schmidlin P, Zobrist K, Attin T, Wegehaupt F. In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides. J Appl Oral Sci. 2016;24:31-6.
  32. Lena Sezici Y, Yetkiner E, Aykut Yetkiner A, Eden E, Attin R. Comparative evaluation of fluoride varnishes, self-assembling peptide-based remineralization agent, and enamel matrix protein derivative on artificial enamel remineralization in vitro. Prog Orthod. 2021;22:4.
  33. Shetty SS, Nekkanti S. Remineralization Potential of a Novel Biomimetic Material (Self-assembling Peptide P11-4) on Early Enamel Caries: An In Vitro Study. J Contemp Dent Pract. 2023;24:181-187.
  34. Silvertown JD, Wong BPY, Sivagurunathan KS, Abrams SH, Kirkham J, Amaechi BT. Remineralization of natural early caries lesions in vitro by P11 -4 monitored with photothermal radiometry and luminescence. J Investig Clin Dent. 2017;8(4).
  35. Sindhura V, Uloopi KS, Vinay C, Chandrasekhar R. Evaluation of enamel remineralizing potential of self-assembling peptide P11-4 on artificially induced enamel lesions in vitro. J Indian Soc Pedod Prev Dent. 2018;36:352-356..
  36. Suda S, Takamizawa T, Takahashi F, Tsujimoto A, Akiba S, Nagura Y, Kurokawa H, Miyazaki M. Application of the Self- Assembling Peptide P11-4 for Prevention of Acidic Erosion. Oper Dent. 2018;43:E166-E172.
  37. Takahashi F, Kurokawa H, Shibasaki S, Kawamoto R, Murayama R, Miyazaki M. Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization. Acta Odontol Scand. 2016;74:142-7.
  38. Tripathi P, Mengi R, Gajare SM, Nanda SS, Wani SA, Kochhar AS. Evaluation of Remineralizing Capacity of P11-4, CPP-ACP, Silver Diamine Fluoride, and NovaMin: An In Vitro Study. J Contemp Dent Pract. 2021;22:357-360.
  39. Üstün N, Aktören O. Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions. Microsc Res Tech. 2019;82:1065-1072.
  40. Uzunova I, Dobrev I, Danalev D, Raycheva R, Georgiev K, Petrova S, Nihtianova T, Belcheva A. Synthesis of fluorenated analogues of self-assembling peptide p11-4 and study on p11-4 therapeutic effect on artificial initial enamel lesions. J Chem Tech Metall 2023;58:511-86.
  41. Xavier GD, Thomas G, Jose S, Vivek VJ, Selvam K, Ramakrishnan A. Comparative evaluation of remineralization potential of four different remineralization agents on human enamel: An in vitro study. J Conserv Dent Endod. 2024;27:29-35.
  42. Yilmaz Sen B, Akcay M. Comparative analysis of the effect of self-assembling peptide P11-4 on enamel erosion: a confocal laser scanning microscopy study. Clin Oral Investig. 2024;29:29.
  43. Yahya MY, Al Rawi NA. Remineralizing Efficacy of Biomimetic Self-Assembling Peptide on Artificially Induced Enamel Lesions (In vitro Study). Journal of Research in Medical and Dental Science 2020;8:406-12.
(D) Original research – Combined in-vitro and in-vivo studies
  1. Metwally, N., Niazy, M., El-Malt, M. Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study). Al-Azhar Dental Journal for Girls 2017;4: 179-188.
(E) Reviews, Narrative reviews, Systematic reviews and meta-analyses
  1. Alkilzy M, Qadri G, Splieth CH, Santamaría RM. Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4. Biomimetics (Basel). 2023;8:290.
  2. Alkilzy M, Santamaria RM, Schmoeckel J, Splieth CH. Treatment of Carious Lesions Using Self-Assembling Peptides. Adv Dent Res. 2018;29:42-47.
  3. Alkilzy M, Splieth CH. Self-assembling peptides for caries prevention and treatment of initial carious lesions, a review. Dtsch Zahnärztl Z Int 2020;2:021–025.
  4. Alsenan D, Rozi A, Alateeq N, Aleban S, Almusallam J. Remineralisation potential of self-assembling peptide (P11-4) compared to other remineralising agents: a narrative review. J Clin Diagn Res. 2024;18.
  5. B K A, R Y, Puranik MP. Remineralization of early enamel caries lesions using self-assembling peptides P11-4: Systematic review and meta-analysis. J Oral Biol Craniofac Res. 2022;12:324-331.
  6. Babu B, Padawe D, Takate V. Remineralization Potential of Self-Assembling Peptides Versus Fluoride Agents in White Spot Lesions: A Systematic Review. Cureus. 2025;17:e95416.
  7. Mohamed RN, Basha S, Al-Thomali Y, Saleh Alshamrani A, Salem Alzahrani F, Tawfik Enan E. Self-assembling peptide P11-4 in remineralization of enamel caries – a systematic review of in-vitro studies. Acta Odontol Scand 2021;79:139-146.
  8. Keeper JH, Kibbe LJ, Thakkar-Samtani M, Heaton LJ, Desrosiers C, Vela K, Amaechi BT, Jablonski-Momeni A, Young DA, MacLean J, Weyant RJ, Zandona AF, Sohn W, Pitts N, Frantsve-Hawley J. Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions. J Am Dent Assoc. 2023;154:580-591.e11.
  9. Keogh A, Alfadil L, Johal A. Contemporary management of white spot lesions following orthodontic treatment. Br Dent J. 2026 Apr;240(8):537-541.
  10. Alkilzy M, Splieth CH. Selbststrukturierende Peptide zur Kariesprävention und Behandlung von Initialkaries läsionen, ein Review. Dtsch Zahnärztl Z 2020;75:62-67.
  11. Gulzar RA, Ajitha P, Subbaiyan H. Self Assembling Peptide P11-4 for Enamel Remineralization: A Biomimetic Approach. J Pharma Res Int 2020;32:83–89.
  12. Venugopal M. Self Assembly Peptides- Biomimetic Material. ARC J Dent Sci 2019;4:5-6.
  13. Santamaría RM, Alkilzy M, Splieth CH, Schmoeckel J. Remineralization of Initial Carious Lesions Using Peptides: A Comprehensive Review. Medicina (Kaunas). 2026;62:1086.
(F) Abstracts, Posters And Paper Presentations, Lectures, Theses, Case Reports, Position papers, Commentaries, Op-eds
  1. Alkilzy M, Tarabaih A, Splieth C. Safety and clinical applicability of Curodont Repair in children with early occlusal caries. Int. Conference for Pediatric Dentistry 2013, Budapest.
  2. Alkilzy M, Tarabaih A, Splieth C. Safety, Clinical Application and Effect of Curodont Repair in Children with Early Occlusal Caries. Caries Res:2014:48:411 (Presented at 61. ORCA Congress, 2014, Greifswald, Deustchland).
  3. Alkilzy M, Tarabaih A, Splieth C. Efficacy, Clinical Applicability and Safety, of CurodontTM Repair in Children with Early Occlusal Caries. Caries Res 2015;49:311 (Presented at 62nd ORCA Congress, 2015, Brussels, Belgium).
  4. Alkilzy M, Santamaria RM, Schmoeckel J, Splieth CH Caries management using self-assembling peptide P11-4 for regenerating initial caries lesions. ICNARA 2017, Napa, CA, USA.
  5. Brigi C. In vitro measurement of dental remineralisation: investigating a biomimetic self-assembling peptide treatment strategy. Master Thesis, Queen Mary, University of London, 2014.
  6. Bröseler F, Tietmann C, Schleich R, Drechsel T, Bommer C. Effect of Curodont™ Repair in Patients with Buccal Carious Lesions: A Mono-centre, Single-blinded, Randomised, Controlled Split-mouth Study – intermediate report. CONSEURO 2013, Paris, France.
  7. Bröseler F, Drechsel T, Tietmann C, Wenzel SP, Schröder J, Bommer C, Jepsen S. Behandlung primär kariöser Schmelzläsionen mittels selbstorganisierender Peptide – erste Daten einer kontrollierten klinischen Studie. Deutscher Zahnärztetag 2015, Frankfurt am Main, Germany.
  8. Brubaker L, Vinh A, Patel S, Solomon E, Amaechi B, Noureldin A. Remineralization of Early-Enamel Lesions Using Biomimetic Regeneration Combined With Fluoride-toothpaste” AADR/CADR Annual Meeting 2016, Los Angeles, USA.
  9. Burke JL. In situ engineering of skeletal tissues using self-assembled biomimetic scaffolds. PhD Thesis, University of Leeds, Leeds Dental Institute, 2011.
  10. Chen X, Gillam DG, Lysek DA, Hill RG. In vitro Evaluation of Dentine Remineralisation by a Self-Assembling Peptide Using Scanning Electron Microscopy. Caries Res 2014;48:402. (Presented at 61. ORCA Congress 2014, Greifswald, Deustchland).
  11. Doberdoli D, Haliti F, Begzati A. Efficacy of Self-assembling Peptide P11-4 with Fluoride Varnish or Self-assembling Peptide Matrix for the Treatment of Early Occlusal Carious Lesions. IADR/AADR/CADR General Session 2019, Presentation 0368, Vancouver, Canada.
  12. Drechsel T. Behandlung initialer Schmelzkaries mittels selbstorganisierender Peptide – Ergebnisse einer radomisierten klinischen Studie. Thesis, Rheinischen Friedrich-Wilhelms-Universität, 2017.
  13. Dziadowiec I, Beckmann F, Thalmann P, Schulz G, Stevanovic S, Kind L, Pieles U, Mueller B. Characterization of natural and artificial carious lesions and their remineralization using self-assembled peptides. SPIE: Developments in X-Ray Tomography IX 2014.
  14. Godenzi D. Give Teeth a Chance: Curodont Repair in daily practice. Lecture at EAPD, Lugano, Switzerland 2018.
  15. Grave A, Poellinger N, Hug M. Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation. 9th EuPFI Conference, 2017, Warsaw.
  16. Hardacker L, Sayed J, Thomson BM, Aggeli A, Kirkham J. An in vitro mineralisation assay to assess capability of self-assembling peptides to nucleate hydroxyapatite de novo. The Leeds Centre for Crystallization – Inaugural Meeting, 2013, School of Earth and Environment, University of Leeds, UK.
  17. Hug M. Biomimetic Mineralization – Novel Strategies for Hard Tissue Regeneration in Dentistry. Swiss Nano Convention 2013, Congress Center Basel, Switzerland.
  18. Jablonski-Momeni A, Korbmacher-Steiner H, Jablonski B, Morawietz M, Kiesow A. Der protektive Effekt des Self-assembling Peptid P11-4 bei Erosionen auf humanem Schmelz – eine randomisierte in-situ Studie. 91. Jahrestagung der DGKFO 2018, Bremen, Deutschland.
  19. Jablonski-Momeni A. Management von initialen kariösen Läsionen – ein aktueller Ansatz. ZMK 2015; 31:2-5.
  20. Jablonski-Momeni A. Emerging Biomimetic technologies in oral care: Self-Assembling Peptides as a biomimetic caries lesion remineralizing agent. COP26 – Global Climate Summit, 2021, Satellite Event Day 1. Editor: Fischer J.
  21. Kamal D, Hassanein EH, Elkassas D, Hamza H. Comparative Evaluation of Remineralizing Efficacy of Biomimetic Self-Assembling Peptide on Artificially Induced Enamel Lesions. 64th ORCA Congress, 2017, Oslo, Norway.
  22. Kilian D. A drug-delivering hydrogel based on self-assembling peptides as a treatment for peri-implantitis. Thesis, 2016, Technische Universität Dresden, Germany.
  23. Kind L, Dziadowiec I, Schulz G, Botta LM, Müller B, Stevanovic S, Deyhle H, Bunk O, Guizar-Sicairos M, Liebi M, Pieles U. Comparing remineralization of natural and artificial carious lesions in human teeth. SPIE Smart Structures/NDE 24, San Diego, USA.
  24. Kind L, Mangeng C, Stevanovic S, Bellon B, Winkler S, Pieles U. Dental caries: Biomimetic treatment and tooth model development. SSB+RM 2015, Lausanne, Switzerland.
  25. Kirkham J, Brunton P. Filling without Drilling: A Biomimetic approach to dental tissue regeneration and repair. British Society of Restorative Dentistry Spring Meeting 2013.
  26. Koch JH. Schmelz bei Kindern regenerieren statt opfern. ZMK 2015;31:826-7.
  27. Knaup T, Korbmacher-Steiner H, Jablonski-Momeni A. Der Einfluss des Self-assembling Peptid P11-4 auf die Scherhaftfestigkeit von Metallbrackets. 91. Jahrestagung der DGKFO, 2018, Bremen, Deutschland.
  28. Knaup T, Korbmacher-Steiner H, Jablonski-Momeni A. Die Auswirkung des kariesprotektiven Peptids P11-4 auf den Haftverbund zwischen Bracket und Zahnschmelz in vitro. DGKFO 2019, Nuremberg, Deutschland.
  29. Lysek DA, Featherstone JD, Wolf M, Ten Cate JM. Self-assembling peptides to support remineralisation of tooth lesions – a biomimetic approach. ICNARA2 2012 Vina Del Mar, Chile.
  30. Mannaa R, Sedlakova P, Bommer C, di Bella E, Krejci I. RCT Investigating the Efficacy of Self-Assembling Peptide for Early Caries. IADR 96th General Session 2018.
  31. Moreira KMS, Puppin-Rontani J. Remineralizing Agent Impact on Resin/demineralized Dentin Bond Longevity: Pilot Study. IADR 2019, Vancouver Canada.
  32. Nath SJC. Biomimetic remineralisation: A comparative evaluation of the enamel remineralisation potential of a short, medium, and long chain self-assembling peptide. Thesis, University of Otago, New Zealand.
  33. Nový BB. Chemical Therapeutics and Non-Restorative Dentistry: Essential Tools During the Pandemic. CDAessentials 2021;8:28-31.
  34. Patel S, Vinh A, Brubaker L, Solomon E, Amaechi B, Noureldin A. In Vitro Assessment of a Novel Biomimetic-Regeneration of Early Caries Lesions. AADR/CADR Annual Meeting 2016, Presentation 1808, Los Angeles, USA.
  35. Ratzmann A, Müller M, Reich M, Krey KF, Welk A. Evaluation von „Self-Assembling“ peptiden in der Initialkariestherapie nach Multibracketbehandlung. 91. Jahrestagung der DGKFO, 2018, Bremen, Deutschland.
  36. Sedlakova P, Krejci I, Lysek D, Bommer C. Effect of Curodont Repair and Fluoride on Remineralisation in Patients with Class 5 Caries – A mono-centre, split-mouth, double-blinded, placebocontrolled, randomised clinical Study. CTI Medtech Event, 2015, Bern, Switzerland.
  37. Stevanovic S, Kind L, Wüthrich A, Pieles U, Hug M, Lysek DA, Porta F, Frommherz A, Deyhle H. Remineralization of carious lesions by self assembled peptide supramolecular networks and Hydroxyapatite nanocrystals. Swiss Nano Convention 2013, Basel.
  38. Stevanovic S, Kind L, Wüthrich A, Porta F, Frommherz A, Deyhle H, Müller B, Pieles U, Hug M, Lysek DA. Remineralization of carious lesions by self assembling peptide supramolecular networks. 19th Swiss Conference on Biomaterials 2013, Davos, Switzerland.
  39. Stevanovic S, Kind L, Wüthrich A, Pieles U, Hug M, Lysek DA. Biomimetic mineralization of carious lesions by a self-assembling peptide. 46. Jahrestagung der AfG 2014, Mainz Germany.
  40. Stevanovic S, Kind L, Grossjohann E, Dziadowiec I, Mueller B, Pieles U. Biomimetic mineralization of early caries lesions with a self-assembling peptide. European Society for Biomaterials 2014, Liverpool, UK.
  41. Takahashi F, Kurokawa H, Takimoto M, Murayama R, Suzuki T, Miyazaki M. Evaluation of Application of Peptide P11-4 on Remineralization of Enamel. AADR/CADR Annual Meeting, Abstract 1804, 2016, Los Angeles, USA.
  42. Takahashi F, Suda S, Sai K, Kurokawa H, Hinoura K, Miyazaki M. Application of the Self-assembling Peptide P11-4 on Acid Erosion Prevention. IADR/AADR/CADR General Session 2017, Presentation 0375, San Francisco, USA.
  43. Welk A. Self-Assembling Peptides in der Therapie von White-Spot-Läsionen. Dt. Zahnärztetag 2018.
  44. Wenger A. Gesteuerte Schmelzregeneration – Effektive kariestherapie zur Vermeidung invasiver Eingriffe. Esthetic Days 2019, Baden-Baden, Deustchland.
  45. Wong B, Silvertown J, Abrams S, Sivagurunathan K, Lysek DA, Amaechi BT. In Vitro Detection of Remineralisation of Early Caries Using Curodont(TM) Repair with the Canary System (R). 61. ORCA Congress 2014, Greifswald, Deustchland.
  46. Wong B, Silvertown J, Abrams S, Sivagurunathan K, Lysek DA, Amaechi BT. Detection of remineralization of early caries with The Canary System. AADR 2014, Charlotte.

CURODONT PROTECT, CURODONT D’SENZ

  1. Alrashid RAY, Abd El-Raouf El-Gazzar RI, Abdelnaby YL. Shear bond strength of metal orthodontic brackets bonded to artificially demineralized enamel treated with three remineralizing agents bonded with AgNP-modified adhesive: An in vitro study. Int Orthod. 2026 Feb 25;24(3):101157.
  2. Ardu S, Varatharaju V, di Bella E, Rossier I, Krejci I. Protection Against Discolouration by Two Over-the Counter Desensitising Products. Oral Health Prev Dent. 2018;16:439-444.
  3. Aşık A, Sağlam C, Elmacı Arslan İ, Önçağ Ö. Comparison of the effect of self-assembling peptide P11-4 on post-bleaching shade stability and microhardness with different bioactive remineralization agents. BMC Oral Health. 2026;26:916.
  4. Baltaci E, Bilmenoglu C, Ozgur O, Ozveren N. Effect of three different remineralising agents on prevention against acidic erosion of primary teeth: an in vitro study. Eur Arch Paediatr Dent. 2023;24:651-659.
  5. Bamidis E, Kunzelmann KH. Evaluation of a Novel Hypersensitivity Relieve Gel Being Applied Prior to Bleaching. 2017 British Division Meeting 2017, Presentation 066, Plymouth, United Kingdom.
  6. Behl M, Taneja S, Bhalla VK. Comparative evaluation of remineralization potential of novel bioactive agents on eroded enamel lesions: A single-blinded in vitro study. J Conserv Dent Endod. 2024 May;27(5):545-551.
  7. Bilge K, Kılıç V. Effects of different remineralizing agents on color stability and surface characteristics of the teeth following vital bleaching. Microsc Res Tech. 2021;84:2206-2218.
  8. Ceci M, Mirando M, Beltrami R, Chiesa M, Colombo M, Poggio C. Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. Scanning. 2016;38:344-51.
  9. Gandy S, Michael A, Jones D, Solomon E, Noureldin A. In-vitro Assessment of Novel Biomimetic-Peptide Versus Fluoride-Varnish in Caries Prevention. IADR/AADR/CADR General Session 2017, San Francisco, California.
  10. Gayas Z, Azher U, Paul ST, Selvan A, Reddy CD, Raghu D, Uday V. Comparative Evaluation of Antimicrobial Efficacy of Fluoride-Based and Self-Assembling Peptide P11-4-based Tooth Remineralization Agents on Streptococcus mutans: A Microbiological Study. Contemp Clin Dent. 2023;14:141-144.
  11. Ghaly YS, El-Wassefy NA, Shamaa MS, Tawfik MA. Effect of self-assembling peptide and other remineralizing agents on preventing initial enamel lesions around orthodontic brackets: An in vitro comparative study. Int Orthod. 2023;21:100751.
  12. Hamouda Y, Elsayed H, Etman W. Biomimetic mineralization approach of dentin hypersensitivity in patients with early non-carious cervical lesions. Egypt Dent J. 2021;76:3693–710.
  13. Hill R, Chen H, Gillam D, Lysek DA. An in vitro comparison of a novel self-assembling peptide matrix gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion. J Dent Maxillofacial Res. 2020;3:1–11.
  14. Jablonski-Momeni A, Korbmacher-Steiner H, Heinzel-Gutenbrunner M, Jablonski B, Jaquet W, Bottenberg P. Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions. Sci Rep. 2019;9:269.
  15. Jablonski-Momeni A, Temming T, Berthold JN, Olbrisch C, Diekmeier C, Bottenberg P, Korbmacher-Steiner H. A prospective, triple-blind, randomized controlled clinical trial evaluating the protective effect of P11-4 peptide on enamel demineralization during multibracket orthodontic treatment. BMC Oral Health. 2026 Jan 9;26(1):379.
  16. Kirchner J. Protective Wirksamkeit von Curodont Protect auf Schmelz und Dentin – Evaluierung durch eine neuartige in vitro Methode. Universität Witten/Herdecke 2016.
  17. Lysek DA, Schlee M, Bommer C. Randomised Clinical Trial Evaluating a Novel Dentine Hypersensitivity Relieve Gel. AADR Annual Meeting, 2016, Los Angeles, USA.
  18. Moras CG, Acharya SR, Adarsh UK, Unnikrishnan VK. Regenerative biomineralization potential of commercially available remineralizing agents as a preventive treatment approach for tooth erosion – An in vitro laser-induced breakdown spectroscopy analysis. J Conserv Dent. 2023;26:165-169.
  19. Mahajan P. A Comparative Evaluation of Biomimetic Remineralization Potential of Enamel White Spot Lesions – An In Vitro Study. Indian J Dent Res. 2025 Aug 14.
  20. Müller P, Heimlinger R, Lukic A, Zumstein T, Bommer C. Evaluation of a tooth gel with Curolox® Technology as part of professional tooth-cleaning, with regards to patient satisfaction and the effects of hypersensitivity. Swiss Dental Hygienists Conference 2013, Lausanne.
  21. Schlee M, Rathe F, Bommer C, Bröseler F, Kind L. Self-assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial. J Periodontol. 2018;89:653-660.
  22. Soares R, De Ataide IN, Fernandes M, Lambor R. Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study. J Clin Diagn Res. 2017;11:ZC136-ZC141.
  23. Stoleriu S, Iovan G, Pancu G, Nica I, Georgescu A, Tofan N, Andrian S, Buhatel D. Study Regarding the Capacity of Self-assembling Peptides to Remineralize the Acute and Chronic Incipient Caries Lesions. Rev Chim (Bucharest) 2019;70:3073-3076.
  24. Vs P. Effect of diode laser on self-assembling peptide enamel remineralization – In vitro study. Bioinformation. 2026 Jan 31;22(1):256-259.

STUDIES TESTING MULTIPLE vVARDIS PRODUCTS

  1. Magalhães GAP, Fraga MAA, de Souza Araújo IJ, Pacheco RR, Correr AB, Puppin-Rontani RM. Effect of a Self-Assembly Peptide on Surface Roughness and Hardness of Bleached Enamel. J Funct Biomater. 2022 Jun 13;13(2):79.

WHITENING WITH vVARDIS TECHNOLOGY

  1. Bommer C, Flessa HP, Xu X, Kunzelmann KH. Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening. J Clin Dent. 2018;29:57-63.
  2. Bommer C, Lysek D, Hug M, Kunzelmann KH, Flessa HP. Tooth-Whitening Effect of a Curolox™-Technology-based Investigational Product. AADR/CADR Annual Meeting, Abstract 1843, 2016, Los Angeles, USA.
  3. Hojabri N. Evaluation of the Whitening Effect of a Mixture of Self-assembling Peptide and Hydroxyapatite on Bovine Enamel. Thesis, LMU Munich, 2019.
  4. Hojabri N, Kaisarly D, Kunzelmann KH. Adhesion and whitening effects of P11-4 self-assembling peptide and HAP suspension on bovine enamel. Clin Oral Investig. 2021;25:3237-3247.
  5. Hojabri N, Kunzelmann KH. Adhesion and whitening efficacy of P11-4 self-assembling peptide and HAP suspension after using NaOCl as a pre-treatment agent. BMC Oral Health. 2022;22:59.
  6. Kunzelmann KH, Lysek DA. Working Mechanism of Tooth Whitening Based on Hydroxyapatite Suspended in a P11-4 Peptide Matrix. IADR/AADR/CADR General Session 2015, Abstract 0838, Boston, Massachusetts, USA.
  7. Xu, X. New Approaches to Tooth Whitening Based on Changing the Optical Properties with Calcium Phosphate Containing Suspensions. Thesis, LMU Munich, 2015.

SELF-ASSEMBLING PEPTIDE TECHNOLOGY

  1. Aggeli A, Bell M, Boden N, Keen JN, Knowles PF, McLeish TC, Pitkeathly M, Radford SE. Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes. Nature. 1997;386:259-62.
  2. Aggeli A, Bell M, Carrick LM, Fishwick CW, Harding R, Mawer PJ, Radford SE, Strong AE, Boden N. pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.” J Am Chem Soc 2003;125:9619-9628.
  3. Aggeli A, Bell M, Boden N, Keen JN, McLeish TCB, Nyrkova I, Radford SE, Semenov A. Engineering of peptide β-sheet nanotapes. J Mater Chem 1997;7:1135-1145.
  4. Araújo IJ, Bertassoni L, Puppin-Rontani RM. P11-4 self-assembly peptide induces biomineralization without cytotoxicity in MDPC-23 cell line. Pulp Biology and Regeneration Group Satellite Meeting 2019, Portland OR, USA.
  5. Araújo IJS, Guimarães GN, Machado RA, Bertassoni LE, Davies RPW, Puppin-Rontani RM. Self-assembly peptide P11-4 induces mineralization and cell-migration of odontoblast-like cells. J Dent. 2022;121:104111.
  6. Bommer C, Waller T, Hilbe M, Wiedemeier D, Meyer N, Mathes S, Jung R. Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs. Clin Oral Investig. 2022;26:3151-3166.
  7. Camassari JR, de Sousa ITC, Cogo-Müller K, Puppin-Rontani RM. The Self-assembling peptide P11-4 influences viability and osteogenic differentiation of stem cells of the apical papilla (SCAP). J Dent 2023;134:104551.
  8. Carrick LM, Aggeli A, Boden N, Fisher J, Ingham E, Waigh TA. Effect of ionic strength on the self-assembly, morphology and gelation of pH responsive β-sheet tape-forming peptides. Tetrahedron 2007;63:7457–7467.
  9. Davies RPW, Howard R, Thomson BM, Brooks SJ, Lysek DA , Kirkham J. Treatment of Fabricated Caries Lesions; Self-Assembling Peptides vs Fluoride. Abstract 143. Caries Res 2015;49:359 (Presented at 62nd ORCA Congress, 2015, Brussels, Belgium).
  10. Davies RPW, Hardaker L, Thomson BM, Howling G, Kirkham J, Lysek DA, Aggeli A. Novel Self-Assembling Peptides, for the Treatment of Early Caries Lesions. Caries Res 2014;48:404-405 (Presented at 61. ORCA Congress, 2014, Greifswald, Deustchland).
  11. de Souza Araújo IJ, Ferreira JA, Daghrery A, Ribeiro JS, Castilho M, Puppin-Rontani RM, Bottino MC. Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. Dent Mater 2022;38:1749-1762.
  12. Davies RPW, Aggeli A, Beevers AJ, Boden N, Carrick LM, Fishwick CWG, Mcleish TCB, I. Nyrkova, Semenov AN. Self-assembling β-Sheet Tape Forming Peptides, Supramolecular Chemistry 2006;18:435-443.
  13. Davies RP. Injectable self-assembling peptide networks. A new route to dental caries treatment. The Leeds Centre for Crystallization – Inaugural Meeting 2013, School of Earth and Environment, University of Leeds.
  14. Davies RPW, Aggeli A, Boden N, McLeish TCB, Nyrkova IA, Semenov AN, Koopmans RJ. Mechanisms and Principles of 1D Self-Assembly of Peptides into [beta]-Sheet Tapes. Adv Chem Eng 2009: 35: 11-43 (Book section).
  15. Davies RP, Aggeli A. Self-assembly of amphiphilic β-sheet peptide tapes based on aliphatic side chains. J Pept Sci. 2011 Feb;17(2):107-14.
  16. de Sousa JP, Carvalho RG, Barbosa-Martins LF, Torquato RJS, Mugnol KCU, Nascimento FD, Tersariol ILS, Puppin-Rontani RM. The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin. J Dent Res. 2019;98:347-354.
  17. El-Sayed B, Davies RPW, El-Zehery RR, Ibrahim FM, Grawish ME, Kirkham J, El-Gendy R. An in-vivo Intraoral Defect Model for Assessing the Use of P11-4 Self-Assembling Peptide in Periodontal Regeneration. Front Bioeng Biotechnol. 2020 Sep 23;8:559494.
  18. Felton SH. (2005). Self-assembling beta-sheet Peptide Networks as Smart Scaffolds for Tissue Engineering (Doctoral dissertation, University of Leeds).
  19. Fernández-Romero E, Toledano M, González-Fernández JF, Osorio R, Vallecillo-Rivas M. Remineralizing potential of self-assembling peptides on dentinal lesions: A systematic review of the literature. J Dent. 2025 Aug;159:105821.
  20. Firth A, Aggeli A, Burke JL, Yang X, Kirkham J. Biomimetic self-assembling peptides as injectable scaffolds for hard tissue engineering. Nanomedicine 2006;1:189–199.
  21. Gonnah R, Parker JE, Davies RPW. Synchrotron X-ray nanoprobe and correlative electron microscopy reveal the role of surface chemistry of self-assembling peptides in calcium phosphate nucleation. Faraday Discuss., 2025:261:132-150.
  22. Gharaei R, Tronci G, Goswami P, Davies RPW, Kirkham J, Russella SJ. Biomimetic peptide enriched nonwoven scaffolds promote calcium phosphate mineralization. RSC Adv 2020;10:28332–28342.
  23. Güner E, Yildirim-Semerci Ö, Altan Z, Arslan-Yildiz A. Peptide-functionalized hydrocolloid bioink for 3D bioprinting in dental tissue engineering. Int J Biol Macromol. 2025 Nov;330(Pt 1):148016.
  24. Hirani RA, Bahramnejad NM, Jones DL, Amaechi BT, Noureldin A. Influence of Surface Deposits on Diffusion of (P11-4) Self-Assembling-Peptide. IADR/AADR/CADR General Session 2017.
  25. Kang J, Davies RP, Brookes SJ, Kirkham J. Multi-level modelling to further understanding of micro-CT data. In proceedings, Enamel 9 conference in Harrogate, University of Leeds, Leeds 2016, Abstract 68.
  26. Kind L. Remineralization of sub-surface carious lesions initiated by a self assembling peptide – Development of a bioceramic tooth model. ILMAC; Präsentationen der Gewinner des SCG FH-Awards 2013, Basel.
  27. Kirkham J, Firth A, Vernals D, Boden N, Robinson C, Shore RC, Brookes SJ, Aggeli A. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007;86:426-30.
  28. Koch F, Meyer N, Valdec S, Jung RE, Mathes SH. Development and application of a 3D periodontal in vitro model for the evaluation of fibrillar biomaterials. BMC Oral Health. 2020;20:148.
  29. Koch F, Müller M, König F, Meyer N, Gattlen J, Pieles U, Peters K, Kreikemeyer B, Mathes S, Saxer S. Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition. R Soc Open Sci. 2018;5:171562.
  30. Koch F, Ekat K, Kilian D, Hettich T, Germershaus O, Lang H, Peters K, Kreikemeyer B. A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential. Adv Healthc Mater. 2019;8:e1900167.
  31. Koch F, Wolff A, Mathes S, Pieles U, Saxer SS, Kreikemeyer B, Peters K. Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro. Int J Nanomedicine. 2018 Oct 23;13:6717-6733.
  32. Koch F, Pieles U. Characterization of network and self-assembling Process of a short sequence peptide for biomimetic therapy. 20th Swiss Conference on Biomaterials and Regenerative Medicine 2014, Basel, Switzerland.
  33. Koch F, Koenig F, Mueller M, Zenobi-Wong M, Pieles U. Matrix design of self assembled peptide hydrogels for hard and soft tissue engineering. 27th European Conference on Biomaterials ESB2015, 2015, Krakow.
  34. Koch F, Ekat K, Kilian D, Mathes S, Pieles U, Peters K, Kreikemeyer B. Self-Assembling Peptides – A New Opportunity to Deal with Periodontal Regeneration. 25th Annual Meeting of the Swiss Society for Biomaterials and Regenerative Medicine 2019, Muttenz.
  35. Koch F, Ekat K, Kilian D, Mathes S, Pieles U, Peters K, Kreikemeyer B. Self-Assembling Peptides – A New Opportunity to Deal with Periodontal Regeneration. Osteology 2019, Barcelona, Spain.
  36. Knapman TW, Aggeli A, Ashcroft AE. Critical concentrations of beta-sheet peptide self-assembly quantified directly by nanoelectrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2008;22: 1611-1614.
  37. Kyle S, Aggeli A, Ingham E, McPherson MJ. Recombinant self-assembling peptides as biomaterials for tissue engineering. Biomaterials 2010;31:9395–9405.
  38. Kyle S, Aggeli A, Ingham E, McPherson MJ. Production of self-assembling biomaterials for tissue engineering. Trends Biotechnol 2009;27: 423-433.
  39. Kyle S, Felton SH, McPherson MJ, Aggeli A, Ingham E. Rational molecular design of complementary self-assembling peptide hydrogels. Adv Healthc Mater 2012;1:640-645.
  40. Maude S, Ingham E, Aggeli A. Biomimetic self-assembling peptides as scaffolds for soft tissue engineering. Nanomedicine (Lond). 2013;8:823-47.
  41. Maude S, Tai LR, Davies RP, Liu B, Harris SA, Kocienski PJ, Aggeli A. Peptide synthesis and self-assembly. Top Curr Chem. 2012;310:27-69.
  42. Meegan JE, Aggeli A, Boden N, Brydson R, Brown AP, Carrick L, Brough AR, Hussain A, Ansell RJ. Designed self-assembled beta-sheet peptide fibrils as templates for silica nanotubes. Adv Funct Mater. 2004;14:31–37.
  43. Melcher M, Facey SJ, Henkes TM, Subkowski T, Hauer B. Accelerated Nucleation of Hydroxyapatite Using an Engineered Hydrophobin Fusion Protein. Biomacromolecules. 2016 May 9;17(5):1716-26.
  44. Meyer N, Koch F, Jung R, Mathes S. In vitro periodontal ligament model to assess synthetic self-assembling peptides for regeneration. Biointerfaces International 2016 Zurich.
  45. Porta F, Kind L, Frommherz A, Stevanovic S, Hug M, Lysek DA, Pieles U. In vitro Models for P11-4 Detection in Dental White Spots. Swiss Nanoconvention 2013, Basel, Deustchland.
  46. Saha S, Yang XB, Wijayathunga N, Harris S, Feichtinger GA, Davies RPW, Kirkham J. A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study. Bone. 2019;127:602-611.
  47. Thomson BM, Hardaker L, Davies RPW, Dennis C, Bronowska A, Aggeli A, Kirkham J, Lysek DA. “P11-15 (NNRFEWEFENN): A biocompatible, self-assembling peptide with potential to promote enamel remineralisation.” Caries Res 2014;48:405. (Presented at 61. ORCA Congress, 2014, Greifswald, Deustchland).
  48. Wilshaw SP, Aggeli A, Fisher J, Ingham E. In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications. Eur Cell and Materials 2008;16(Suppl 3):97.
  49. Kind L, Stevanovic S, Wuttig S, Wimberger S, Hofer J, Müller B, Pieles U. Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide. J Dent Res. 2017;96:790-797.
  50. Carvalho RG, Patekoski LF, Puppin-Rontani RM, Nakaie CR, Nascimento FD, Tersariol ILS. Self-assembled peptide P11-4 interacts with the type I collagen C-terminal telopeptide domain and calcium ions. Dent Mater. 2023;39:708.
  51. Warren JP, Culbert MP, Miles DE, Maude S, Wilcox RK, Beales PA. Controlling the Self-Assembly and Material Properties of β-Sheet Peptide Hydrogels by Modulating Intermolecular Interactions. Gels. 2023;9:441.
  52. Waller T, Bommer C, Hug M, Mathes S, Koch F, Wiedemeier DB, Paqué F, Jung R. Effects of Self-Assembling Peptide P11-4 on Periodontal-Regenerative Surgery – An Acute Dehiscence Model in Dogs. Europerio9, 2018, Amsterdam, Netherlands.
  53. Waller T, Bommer C, Lysek DA, Hug M, Mathes S, Koch F, Wiedemeier DB, Jung R. Efficacy and safety of self-assembling peptide P11-4 in periodontal regeneration – an acute dehiscence model in dogs. Osteology, 2019, Barcelona, Spain.
  54. Wu LC, Yang J, Kopeček J. Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds. Biomaterials. 2011 Aug;32(23):5341-53.
  55. Protopapa E, Ringstad L, Aggeli A, Nelson A. Interaction of self-assembling β-sheet peptides with phospholipid monolayers: The effect of serine, threonine, glutamine and asparagine amino acid side chains. Electrochimica Acta 2010;55:3368-3375.
  56. Regenass S, Bühler T, Gianfreda E, Kind L, Hug M, Lysek DA. Kinetic characterization of the P11-4 self-assembly behaviour. Thesis, NanoLab, FHNW – School of Life Sciences. Muttenz. 2021.
  57. Barco A, Ingham E, Fisher J, Fermor H, Davies RPW. On the design and efficacy assessment of self-assembling peptide-based hydrogel-glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration. J Pept Sci. 2018 Aug;24(8-9):e3114.
  58. Scanlon S, Aggeli A, Boden N, McLeish TCB, Hine P, Koopmans RJ, Crowdere C. Organisation of self-assembling peptide nanostructures into macroscopically ordered lamella-like layers by ice crystallization. Soft Matter, 2009,5, 1237-1246.
  59. Holanda R, Barbosa-Martins LF, Sousa J, Moreira KMS, da Silva J, Puppin-Rontani J. P11-4 a Self-assembly Peptide Doesn’t affect the resin/dentin bonding interface. IADR/AADR/CADR General Session 2019, Vancouver Canada.
  60. Zhang OL, Niu JY, Yu OY, Mei ML, Jakubovics NS, Chu CH. Peptide Designs for Use in Caries Management: A Systematic Review. Int J Mol Sci. 2023 Feb 20;24(4):4247.
  61. Sousa J, Carvalho RG, Barbosa-Martins LF, Tersario IL, Nascimento FD, Puppin-Rontani RM. Peptide P11-4 acts as a nucleator of hydroxyapatite crystals formation. J Dent Res 2017;96 (Spec. Iss. A):3297.
  62. Altenburger MJ, Jäger B, Wrbas K-T, Hellwig E. Peptide Scaffolds to Support Remineralization of Initial Carious Lesions – In Vitro. Caries Res 2014:48:404.
  63. Hardan L, Chedid JCA, Bourgi R, Cuevas-Suárez CE, Lukomska-Szymanska M, Tosco V, Monjarás-Ávila AJ, Jabra M, Salloum-Yared F, Kharouf N, Mancino D, Haikel Y. Peptides in Dentistry: A Scoping Review. Bioengineering (Basel). 2023 Feb 6;10(2):214.
  64. El-Sayed B, El-Zehery RR, Ibrahim FM, Grawish ME, Kirkham J, El-Gendy R Periodontal Regeneration in a Rat Model Using Self-Assembling Peptides. BSODR 2017, Plymouth, GB.
  65. Prakash A, Parsons SJ, Kyle S, McPherson MJ. Recombinant production of self-assembling β-structured peptides using SUMO as a fusion partner. Microb Cell Fact. 2012 Jul 3;11:92.
  66. Guilliatt RS. Self-assembling functionalised peptides into decellularised materials for application in small diameter vascular grafts. Thesis, University of Leeds 2013.
  67. Whitworth SA. Self-assembling Peptide Nano-Apatite Hybrid Material for Dentine Mineralisation. Thesis, University of Leeds, 2018.
  68. Bell CJ, Carrick LM, Katta J, Jin Z, Ingham E, Aggeli A, Boden N, Waigh TA, Fisher J. Self-assembling peptides as injectable lubricants for osteoarthritis. J Biomed Mater Res A. 2006 Aug;78(2):236-46.
  69. Mathes S, Jund R, Hug M. Self-Assembling Peptides As Novel Treatment Strategy To Regenerate Periodontal Ligament. Swiss Medtech Day 2017 Bern.
  70. Kyle S. Self-assembling peptides as scaffolds for tissue engineering. PhD thesis, 2010, University of Leeds.
  71. Meyer N, Koch F, Hug M, Jung R, Mathes S. Self-Assembling Peptides for Regneration of the Periodontal Ligament. CTI Medtech Event 2015.
  72. Kyle S, Riley E, Aggeli A, Ingham E, McPherson MJ. Self-Assembling Peptides for Scaffolds in Regenerative Medicine: Production Using Recombinant DNA Technology. Termis EU 2008, Porto, Portugal.
  73. Seow WY, Hauser CAE. Short to ultrashort peptide hydrogels for biomedical uses. Materials Today 2014;17:381-88.
  74. Kind L, Saxer S, Koch F, Pieles U. Synthetic Bone Regenerative Matrix. Osteology 2019 Barcelona, Spain.
  75. Kind L. Synthetic composite matrix for dental bone regeneration. 25th Annual Meeting of the Swiss Society for Biomaterials and Regenerative Medicine 2019.
  76. Wilshaw SP, Aggeli A, Fisher J, Ingham E. The Biocompatibility and Immunogenicity of Self-Assembling Peptides for Use in Tissue Engineering and Regenerative Applications. Termis EU 2008, Porto Portugal.

REVIEW ARTICLES INCLUDING SELF-ASSEMBLING PEPTIDES

  1. Acharya G, Agrawal P, Patri G. Recent Biomimetic Advances in Rebuilding Lost Enamel Structure. J Int Oral Health 2016;8:527-535.
  2. Amaechi BT. Remineralization therapies for initial caries lesions. Current oral Health Reports 2015;2:95-101.
  3. Amaechi BT. Remineralization – the buzzword for early MI caries management. Br Dent J 2017;223: 173-182.
  4. Arifa MK, Ephraim R, Rajamani T. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent. 2019;12:139-144.
  5. Bonchev A, Vasileva R, Dyulgerova E, Yantcheva S. Self-assembling Peptide P11-4: A Biomimetic Agent for Enamel Remineralization. Int J Pept Res Ther 2021;27:899–907.
  6. Braga RR, Habelitz S. Current Developments on Enamel and Dentin Remineralization. Curr Oral Health Rep 2019:6:257–263.
  7. Buzalaf MAR, Pessan JP. New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization. Monogr Oral Sci. 2017;26:88-96.
  8. Cagna DR, Donovan TE, McKee JR, Eichmiller F, Metz JE, Albouy JP, Marzola R, Murphy KG, Troeltzsch M. Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry. J Prosthet Dent. 2021 Sep;126(3):276-359.
  9. Cagna DR, Donovan TE, McKee JR, Metz JE, Marzola R, Murphy KG, Troeltzsch M. Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry. J Prosthet Dent. 2024 Dec;132(6):1133-1214.
  10. Cabalén MB, Molina GF, Bono A, Burrow MF. Nonrestorative Caries Treatment: A Systematic Review Update. Int Dent J. 2022 Dec;72(6):746-764.
  11. Clarkson BH, Exterkate RA. Noninvasive dentistry: a dream or reality? Caries Res. 2015;49 Suppl 1:11-7.
  12. Cosma LL, Şuhani RD, Mesaroş A, Badea ME. Current treatment modalities of orthodontically induced white spot lesions and their outcome – a literature review. Med Pharm Rep. 2019 Jan;92(1):25-30.
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