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Table of Contents

CURODONT™ REPAIR

(A) Original research – Clinical trials
  1. Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH. Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel. J Dent Res. 2018;97:148-154.
  2. Atteya SM, Amer HA, Saleh SM, Safwat Y. Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial. BMC Oral Health. 2023;23:577.
  3. Aziz FA, Marei TH, Elmalt MA. Assessment of self-assembling peptide P 11-4 in the treatment of white spot lesions after orthodontic treatment. Egyptian Orthodontic Journal. 2016;50:35-48.
  4. Bröseler F, Tietmann C, Bommer C, Drechsel T, Heinzel-Gutenbrunner M, Jepsen S. Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries. Clin Oral Investig. 2020;24:123-132
  5. Brunton PA, Davies RP, Burke JL, Smith A, Aggeli A, Brookes SJ, Kirkham J. Treatment of early caries lesions using biomimetic self-assembling peptides–a clinical safety trial. Br Dent J. 2013;215:E6
  6. Kamh RA, Niazy MA, El-Yasaky MA. Clinical Performance and Remineralization Potential of Different Biomimitic Materials on White Spot Lesions. Al-Azhar Dental Journal for Girls, 2018;5:349-358
  7. Kobeissi R, Badr SB, Osman E. Effectiveness of Self-assembling Peptide P11-4 Compared to Tricalcium Phosphate Fluoride Varnish in Remineralization of White Spot Lesions: A Clinical Randomized Trial. Int J Clin Pediatr Dent. 2020;13:451-456.
  8. Natchiyar N, Asokan S, Priya GP, Viswanath S. Comparison of Remineralizing Agents in the Management of White Spot Lesions In Three- to Five-year-old Children: a Clinical Trial. Pediatr Dent. 2023;45:99-106.
  9. Schlee M, Schad T, Koch JH, Cattin PC, Rathe F. Clinical performance of self-assembling peptide P11 -4 in the treatment of initial proximal carious lesions: A practice-based case series. J Investig Clin Dent. 2018 Feb;9(1)
  10. Schlee, M., Rathe, F., Huck, T. et al. Klinischer Effekt biomimetischer Mineralisation bei Approximalkaries. Stomatologie 2014;111:175–181
  11. Sedlakova Kondelova P, Mannaa A, Bommer C, Abdelaziz M, Daeniker L, di Bella E, Krejci I. Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial. Sci Rep. 2020;10:20211.
  12. Shah SV, Kibbe LJ, Heaton LJ, Desrosiers C, Wittenborn J, Filipova M, Zaydenman K, Keeper JH. Framework for fiscal impact analysis of managing initial caries lesions with noninvasive therapies. J Am Dent Assoc. 2023;154:897-909.e6.
  13. Welk A, Ratzmann A, Reich M, Krey KF, Schwahn C. Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions. Sci Rep. 2020;10:6819.
(B) Original research – clinical trials testing Curodont Repair + Curodont Protect
  1. Doberdoli D, Bommer C, Begzati A, Haliti F, Heinzel-Gutenbrunner M, Juric H. Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Sci Rep. 2020;10:4195
  2. Godenzi D, Bommer C, Heinzel-Gutenbrunner M, Horst Keeper J, Peters K. Remineralizing potential of the biomimetic P11-4 self-assembling peptide on noncavitated caries lesions: A retrospective cohort study evaluating semistandardized before-and-after radiographs. J Am Dent Assoc. 2023:S0002-8177(23)00416-6
(C) Original trials – In vitro studies
  1. Barbosa-Martins LF, de Sousa JP, de Castilho ARF, Puppin-Rontani J, Davies RPW, Puppin-Rontani RM. Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents. J Mech Behav Biomed Mater. 2018;81:214-221
  2. Barbosa-Martins LF, Sousa JP, Alves LA, Davies RPW, Puppin-Rontanti RM. Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin. Materials (Basel). 2018;11:1733
  3. Deyhle H, Dziadowiec I, Kind L, Thalmann P, Schulz G, Müller B. Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach. Dent J 2015;3:111-122
  4. Jablonski-Momeni A, Heinzel-Gutenbrunner M. Efficacy of the “Self-assembling peptide P11-4” in the formation of a remineralization scaffold on artificially induced enamel lesions on smooth surfaces.” J Orofac Orthop 2014;75:175-190
  5. Jablonski-Momeni A, Nothelfer R, Morawietz M, Kiesow A, Korbmacher-Steiner H. Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets. Sci Rep. 2020;10:15132
  6. Kamal D, Hassanein H, Elkassas D, Hamza H. Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An in vitro study. J Conserv Dent. 2018;21:536-541
  7. Kamal D, Hassanein H, Elkassas D, Hamza H. Complementary remineralizing effect of self-assembling peptide (P11-4) with CPP-ACPF or fluoride: An in vitro study. J Clin Exp Dent. 2020;12:e161-e168
  8. Knaup T, Korbmacher-Steiner H, Jablonski-Momeni A. Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets. J Orofac Orthop. 2021;82:329-336.
  9. Kucukyilmaz E, Savas S. Measuring the remineralization potential of different agents with quantitative light-induced fluorescence digital Biluminator. J Appl Biomater Funct Mater. 2017;15:e101-e106
  10. Moreira KM, Bertassoni LE, Davies RP, Joia F, Höfling JF, Nascimento FD, Puppin-Rontani RM. Impact of biomineralization on resin/biomineralized dentin bond longevity in a minimally invasive approach: An “in vitro” 18-month follow-up. Dent Mater. 2021;37:e276-e289.
  11. Nath SJC, Fu Y, Li KC, Loho T, Loch C, Ekambaram M. A Comparison of the Enamel Remineralisation Potential of Self-Assembling Peptides. Int Dent J. 2023 Sep 22:S0020-6539(23)00123-5
  12. Özdemir Ş, Taran PK, Mammadlı N, Altınova İS, Gazioğlu I. Remineralization potential of P11-4 and fluoride on secondary carious primary enamel: A quantitative evaluation using microcomputed tomography. Microsc Res Tech. 2022;85:807-812
  13. Savas S, Kucukyilmaz E, Celik EU. Effects of Remineralization Agents on Artificial Carious Lesions. Pediatr Dent. 2016;38:511-518.
  14. Schmidlin P, Zobrist K, Attin T, Wegehaupt F. In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides. J Appl Oral Sci. 2016;24:31-6.
  15. Lena Sezici Y, Yetkiner E, Aykut Yetkiner A, Eden E, Attin R. Comparative evaluation of fluoride varnishes, self-assembling peptide-based remineralization agent, and enamel matrix protein derivative on artificial enamel remineralization in vitro. Prog Orthod. 2021;22:4
  16. Shetty SS, Nekkanti S. Remineralization Potential of a Novel Biomimetic Material (Self-assembling Peptide P11-4) on Early Enamel Caries: An In Vitro Study. J Contemp Dent Pract. 2023;24:181-187.
  17. Silvertown JD, Wong BPY, Sivagurunathan KS, Abrams SH, Kirkham J, Amaechi BT. Remineralization of natural early caries lesions in vitro by P11 -4 monitored with photothermal radiometry and luminescence. J Investig Clin Dent. 2017;8(4).
  18. Sindhura V, Uloopi KS, Vinay C, Chandrasekhar R. Evaluation of enamel remineralizing potential of self-assembling peptide P11-4 on artificially induced enamel lesions in vitro. J Indian Soc Pedod Prev Dent. 2018;36:352-356.
  19. Suda S, Takamizawa T, Takahashi F, Tsujimoto A, Akiba S, Nagura Y, Kurokawa H, Miyazaki M. Application of the Self- Assembling Peptide P11-4 for Prevention of Acidic Erosion. Oper Dent. 2018;43:E166-E172
  20. Takahashi F, Kurokawa H, Shibasaki S, Kawamoto R, Murayama R, Miyazaki M. Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization. Acta Odontol Scand. 2016;74:142-7
  21. Tripathi P, Mengi R, Gajare SM, Nanda SS, Wani SA, Kochhar AS. Evaluation of Remineralizing Capacity of P11-4, CPP-ACP, Silver Diamine Fluoride, and NovaMin: An In Vitro Study. J Contemp Dent Pract. 2021;22:357-360
  22. Üstün N, Aktören O. Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions. Microsc Res Tech. 2019;82:1065-1072.
(D) Original research – Combined in-vitro and in-vivo studies
  1. Metwally, N., Niazy, M., El-Malt, M. Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study). Al-Azhar Dental Journal for Girls 2017;4: 179-188.
(E) Reviews, Systematic reviews and meta-analyses
  1. Alkilzy M, Qadri G, Splieth CH, Santamaría RM. Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4. Biomimetics (Basel). 2023;8:290.
  2. Alkilzy M, Santamaria RM, Schmoeckel J, Splieth CH. Treatment of Carious Lesions Using Self-Assembling Peptides. Adv Dent Res. 2018;29:42-47
  3. Alkilzy M, Splieth CH. Self-assembling peptides for caries prevention and treatment of initial carious lesions, a review. Dtsch Zahnärztl Z Int 2020;2:021–025
  4. B K A, R Y, Puranik MP. Remineralization of early enamel caries lesions using self-assembling peptides P11-4: Systematic review and meta-analysis. J Oral Biol Craniofac Res. 2022;12:324-331.
  5. Mohamed RN, Basha S, Al-Thomali Y, Saleh Alshamrani A, Salem Alzahrani F, Tawfik Enan E. Self-assembling peptide P11-4 in remineralization of enamel caries – a systematic review of in-vitro studies. Acta Odontol Scand 2021;79:139-146.
  6. Keeper JH, Kibbe LJ, Thakkar-Samtani M, Heaton LJ, Desrosiers C, Vela K, Amaechi BT, Jablonski-Momeni A, Young DA, MacLean J, Weyant RJ, Zandona AF, Sohn W, Pitts N, Frantsve-Hawley J. Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions. J Am Dent Assoc. 2023;154:580-591.e11.
(F) Abstracts, Posters And Paper Presentations, Lectures, Theses
  1. Doberdoli D, Haliti F, Begzati A. Efficacy of Self-assembling Peptide P11-4 with Fluoride Varnish or Self-assembling Peptide Matrix for the Treatment of Early Occlusal Carious Lesions. IADR/AADR/CADR General Session 2019, Presentation 0368, Vancouver, Canada
  2. Davies RPW, Howard R, Thomson BM, Brooks SJ, Lysek DA , Kirkham J. Treatment of Fabricated Caries Lesions; Self-Assembling Peptides vs Fluoride. Abstract 143. Caries Res 2015;49:359
  3. Takahashi F, Kurokawa H, Takimoto M, Murayama R, Suzuki T, Miyazaki M. Evaluation of Application of Peptide P11-4 on Remineralization of Enamel. AADR/CADR Annual Meeting, Abstract 1804, 2016, Los Angeles, USA.
  4. Takahashi F, Suda S, Sai K, Kurokawa H, Hinoura K, Miyazaki M. Application of the Self-assembling Peptide P11-4 on Acid Erosion Prevention. IADR/AADR/CADR General Session 2017, Presentation 0375, San Francisco, USA
  5. Patel S, Vinh A, Brubaker L, Solomon E, Amaechi B, Noureldin A. In Vitro Assessment of a Novel Biomimetic-Regeneration of Early Caries Lesions. AADR/CADR Annual Meeting 2016, Presentation 1808, Los Angeles, USA.
  6. Brubaker L, Vinh A, Patel S, Solomon E, Amaechi B, Noureldin A. Remineralization of Early-Enamel Lesions Using Biomimetic Regeneration Combined With Fluoride-toothpaste” AADR/CADR Annual Meeting 2016, Abstract 1809, Los Angeles, USA.
  7. Godenzi D. Give Teeth a Chance: Curodont Repair in daily practice. Lecture at EAPD, Lugano, Switzerland 2018
  8. Brigi C. In vitro measurement of dental remineralisation: investigating a biomimetic self-assembling peptide treatment strategy. Master Thesis, Queen Mary, University of London, 2014
  9. Burke JL. In situ engineering of skeletal tissues using self-assembled biomimetic scaffolds. PhD Thesis, University of Leeds, Leeds Dental Institute, 2011

CURODONT PROTECT and CURODONT D’SENZ

  1. Ardu S, Varatharaju V, di Bella E, Rossier I, Krejci I. Protection Against Discolouration by Two Over-the Counter Desensitising Products. Oral Health Prev Dent. 2018;16:439-444.
  2. Bamidis E, Kunzelmann KH. Evaluation of a Novel Hypersensitivity Relieve Gel Being Applied Prior to Bleaching. 2017 British Division Meeting 2017, Presentation 066, Plymouth, United Kingdom.
  3. Baltaci E, Bilmenoglu C, Ozgur O, Ozveren N. Effect of three different remineralising agents on prevention against acidic erosion of primary teeth: an in vitro study. Eur Arch Paediatr Dent. 2023;24:651-659
  4. Bilge K, Kılıç V. Effects of different remineralizing agents on color stability and surface characteristics of the teeth following vital bleaching. Microsc Res Tech. 2021;84:2206-2218.
  5. Ceci M, Mirando M, Beltrami R, Chiesa M, Colombo M, Poggio C. Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. Scanning. 2016;38:344-51.
  6. Chen X, Gillam DG, Lysek DA, Hill RG. In vitro Evaluation of Dentine Remineralisation by a Self-Assembling Peptide Using Scanning Electron Microscopy. Abstract 40 Caries Res 2014;48:402.
  7. Gayas Z, Azher U, Paul ST, Selvan A, Reddy CD, Raghu D, Uday V. Comparative Evaluation of Antimicrobial Efficacy of Fluoride-Based and Self-Assembling Peptide P11-4-based Tooth Remineralization Agents on Streptococcus mutans: A Microbiological Study. Contemp Clin Dent. 2023;14:141-144
  8. Ghaly YS, El-Wassefy NA, Shamaa MS, Tawfik MA. Effect of self-assembling peptide and other remineralizing agents on preventing initial enamel lesions around orthodontic brackets: An in vitro comparative study. Int Orthod. 2023;21:100751.
  9. Hamouda Y, Elsayed H, Etman W. Biomimetic mineralization approach of dentin hypersensitivity in patients with early non-carious cervical lesions. Egypt Dent J. 2021;76:3693–710
  10. Hill R, Chen H, Gillam D, Lysek DA. An in vitro comparison of a novel self-assembling peptide matrix gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion. J Dent Maxillofacial Res. 2020;3:1–11
  11. Jablonski-Momeni A, Korbmacher-Steiner H, Heinzel-Gutenbrunner M, Jablonski B, Jaquet W, Bottenberg P. Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions. Sci Rep. 2019;9:269.
  12. Moras CG, Acharya SR, Adarsh UK, Unnikrishnan VK. Regenerative biomineralization potential of commercially available remineralizing agents as a preventive treatment approach for tooth erosion – An in vitro laser-induced breakdown spectroscopy analysis. J Conserv Dent. 2023;26:165-169.
  13. Müller P, Heimlinger R, Lukic A, Zumstein T, Bommer C. Evaluation of a tooth gel with Curolox® Technology as part of professional tooth-cleaning, with regards to patient satisfaction and the effects of hypersensitivity. Swiss Dental Hygienists Conference 2013, Lausanne.
  14. Saxer UP et al. Efficacy of CURODONT™ D’SENZ to reduce tooth sensitivity when applied before professional dental cleaning. Internal Report, 2014.
  15. Schlee M, Rathe F, Bommer C, Bröseler F, Kind L. Self-assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial. J Periodontol. 2018;89:653-660
  16. Soares R, De Ataide IN, Fernandes M, Lambor R. Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study. J Clin Diagn Res. 2017;11:ZC136-ZC141.
  17. Stoleriu S, Iovan G, Pancu G, Nica I, Georgescu A, Tofan N, Andrian S, Buhatel D. Study Regarding the Capacity of Self-assembling Peptides to Remineralize the Acute and Chronic Incipient Caries Lesions. Rev Chim (Bucharest) 2019;70:3073-3076

STUDIES TESTING MULTIPLE vVARDIS PRODUCTS

  1. Magalhães GAP, Fraga MAA, de Souza Araújo IJ, Pacheco RR, Correr AB, Puppin-Rontani RM. Effect of a Self-Assembly Peptide on Surface Roughness and Hardness of Bleached Enamel. J Funct Biomater. 2022 Jun 13;13(2):79.

WHITENING WITH vVARDIS TECHNOLOGY

  1. Bommer C, Flessa HP, Xu X, Kunzelmann KH. Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening. J Clin Dent. 2018;29:57-63.
  2. Bommer C, Lysek D, Hug M, Kunzelmann KH, Flessa HP. Tooth-Whitening Effect of a Curolox™-Technology-based Investigational Product. AADR/CADR Annual Meeting, Abstract 1843, 2016, Los Angeles, USA.
  3. Hojabri N. Evaluation of the Whitening Effect of a Mixture of Self-assembling Peptide and Hydroxyapatite on Bovine Enamel. Thesis, LMU Munich, 2019
  4. Hojabri N, Kaisarly D, Kunzelmann KH. Adhesion and whitening effects of P11-4 self-assembling peptide and HAP suspension on bovine enamel. Clin Oral Investig. 2021;25:3237-3247.
  5. Hojabri N, Kunzelmann KH. Adhesion and whitening efficacy of P11-4 self-assembling peptide and HAP suspension after using NaOCl as a pre-treatment agent. BMC Oral Health. 2022;22:59.
  6. Kunzelmann KH, Lysek DA. Working Mechanism of Tooth Whitening Based on Hydroxyapatite Suspended in a P11-4 Peptide Matrix. IADR/AADR/CADR General Session 2015, Abstract 0838, Boston, Massachusetts, USA.
  7. Xu, X. New Approaches to Tooth Whitening Based on Changing the Optical Properties with Calcium Phosphate Containing Suspensions. Thesis, LMU Munich, 2015
  8. Focus Group. Effectiveness and Reception of a novel non-peroxide whitening product as judged by consumers. New York & Los Angeles, Internal Report, 2019

SELF-ASSEMBLING PEPTIDE TECHNOLOGY

  1. Aggeli A, Bell M, Boden N, Keen JN, Knowles PF, McLeish TC, Pitkeathly M, Radford SE. Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes. Nature. 1997;386:259-62
  2. Aggeli A, Bell M, Carrick LM, Fishwick CW, Harding R, Mawer PJ, Radford SE, Strong AE, Boden N. pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.” J Am Chem Soc 2003;125:9619-9628.
  3. Araujo IJ et al. P11-4 self-assembly peptide induces biomineralization without cytotoxicity in MDPC-23 cell line. Pulp Biology and Regeneration Group Satellite Meeting 2019, Portland OR, USA
  4. Araújo IJS, Guimarães GN, Machado RA, Bertassoni LE, Davies RPW, Puppin-Rontani RM. Self-assembly peptide P11-4 induces mineralization and cell-migration of odontoblast-like cells. J Dent. 2022;121:104111.
  5. de Souza Araújo IJ, Ferreira JA, Daghrery A, Ribeiro JS, Castilho M, Puppin-Rontani RM, Bottino MC. Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. Dent Mater 2022;38:1749-1762.
  6. Bommer C, Waller T, Hilbe M, Wiedemeier D, Meyer N, Mathes S, Jung R. Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs. Clin Oral Investig. 2022;26:3151-3166.
  7. Carrick LM, Aggeli A, Boden N, Fisher J, Ingham E, Waigh TA. Effect of ionic strength on the self-assembly, morphology and gelation of pH responsive β-sheet tape-forming peptides. ChemInform 2007;63:7457–7467.
  8. Camassari JR, de Sousa ITC, Cogo-Müller K, Puppin-Rontani RM. The Self-assembling peptide P11-4 influences viability and osteogenic differentiation of stem cells of the apical papilla (SCAP). J Dent 2023;134:104551
  9. Davies RPW, Hardaker L, Thomson BM, Howling G, Kirkham J, Lysek DA, Aggeli A. Novel Self-Assembling Peptides, for the Treatment of Early Caries Lesions. Caries Res 2014;48:404-405
  10. Davies RPW, Aggeli A, Beevers AJ, Boden N, Carrick LM, Fishwick CWG, Mcleish TCB, I. Nyrkova, Semenov AN. Self-assembling β-Sheet Tape Forming Peptides, Supramolecular Chemistry 2006;18:435-443
  11. de Sousa JP, Carvalho RG, Barbosa-Martins LF, Torquato RJS, Mugnol KCU, Nascimento FD, Tersariol ILS, Puppin-Rontani RM. The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin. J Dent Res. 2019;98:347-354
  12. Felton SH. (2005). Self-assembling beta-sheet Peptide Networks as Smart Scaffolds for Tissue Engineering (Doctoral dissertation, University of Leeds).
  13. Firth A, Aggeli A, Burke JL, Yang X, Kirkham J. Biomimetic self-assembling peptides as injectable scaffolds for hard tissue engineering. Nanomedicine 2006;1:189–199.
  14. Gharaei R, Tronci G, Goswami P, Davies RPW, Kirkham J, Russella SJ. Biomimetic peptide enriched nonwoven scaffolds promote calcium phosphate mineralization. RSC Adv 2020;10:28332–28342
  15. Kang J, Davies RP, Brookes SJ, Kirkham J. Multi-level modelling to further understanding of micro-CT data. In proceedings, Enamel 9 conference in Harrogate, University of Leeds, Leeds 2016, Abstract 68
  16. Kirkham J, Firth A, Vernals D, Boden N, Robinson C, Shore RC, Brookes SJ, Aggeli A. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007;86:426-30
  17. Koch F, Meyer N, Valdec S, Jung RE, Mathes SH. Development and application of a 3D periodontal in vitro model for the evaluation of fibrillar biomaterials. BMC Oral Health. 2020;20:148.
  18. Koch F, Müller M, König F, Meyer N, Gattlen J, Pieles U, Peters K, Kreikemeyer B, Mathes S, Saxer S. Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition. R Soc Open Sci. 2018;5:171562.
  19. Koch F, Ekat K, Kilian D, Hettich T, Germershaus O, Lang H, Peters K, Kreikemeyer B. A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential. Adv Healthc Mater. 2019;8:e1900167.
  20. Kyle S, Aggeli A, Ingham E, McPherson MJ. Recombinant self-assembling peptides as biomaterials for tissue engineering. Biomaterials 2010;31:9395–9405.
  21. Kyle S et al. The self-assembling peptide, P11-4 for a scaffold in regenerative medicine.” Eur Cell and Materials 2008;16(Suppl 3):70.
  22. Maude S, Ingham E, Aggeli A. Biomimetic self-assembling peptides as scaffolds for soft tissue engineering. Nanomedicine (Lond). 2013;8:823-47.
  23. Saha S, Yang XB, Wijayathunga N, Harris S, Feichtinger GA, Davies RPW, Kirkham J. A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study. Bone. 2019;127:602-611
  24. de Sousa JP, Carvalho RG, Barbosa-Martins LF, Torquato RJS, Mugnol KCU, Nascimento FD, Tersariol ILS, Puppin-Rontani RM. The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin. J Dent Res. 2019;98:347-354
  25. Wilshaw, S. P., A. Aggeli, et al. In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications. Eur Cell and Materials 2008;16(Suppl 3):97
  26. Kind L, Stevanovic S, Wuttig S, Wimberger S, Hofer J, Müller B, Pieles U. Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide. J Dent Res. 2017;96:790-797
  27. Carvalho RG, Patekoski LF, Puppin-Rontani RM, Nakaie CR, Nascimento FD, Tersariol ILS. Self-assembled peptide P11-4 interacts with the type I collagen C-terminal telopeptide domain and calcium ions. Dent Mater. 2023;39:708.

REVIEW ARTICLES INCLUDING SELF-ASSEMBLING PEPTIDES

  1. Acharya G, Agrawal P, Patri G. Recent Biomimetic Advances in Rebuilding Lost Enamel Structure. J Int Oral Health 2016;8:527-535
  2. Amaechi BT. Remineralization therapies for initial caries lesions. Current oral Health Reports 2015;2:95-101
  3. Amaechi BT. Remineralization – the buzzword for early MI caries management. Br Dent J 2017;223: 173-182
  4. Arifa MK, Ephraim R, Rajamani T. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent. 2019;12:139-144
  5. Bonchev A, Vasileva R, Dyulgerova E, Yantcheva S. Self-assembling Peptide P11-4: A Biomimetic Agent for Enamel Remineralization. Int J Pept Res Ther 2021;27:899–907.
  6. Buzalaf MAR, Pessan JP. New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization. Monogr Oral Sci. 2017;26:88-96.
  7. Clarkson BH, Exterkate RA. Noninvasive dentistry: a dream or reality? Caries Res. 2015;49 Suppl 1:11-7.
  8. Donovan TE, Marzola R, Becker W, Cagna DR, Eichmiller F, McKee JR, Metz JE, Albouy JP. Annual review of selected scientific literature: report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry. J Prosthet Dent. 2014;112:1038-87.
  9. González-Cabezas C, Fernández CE. Recent Advances in Remineralization Therapies for Caries Lesions. Adv Dent Res. 2018;29:55-59.
  10. Pandya M, Diekwisch TGH. Enamel biomimetics-fiction or future of dentistry. Int J Oral Sci. 2019;11:8
  11. Philip N. State of the art enamel remineralization systems: the next frontier in caries management. Caries Res 2019b;53:284–295
  12. Pitts N. Summary of: Treatment of early caries lesions using biomimetic self-assembling peptides–a clinical safety trial. Br Dent J. 2013;215:174-5

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