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Keeper JH et al. Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions. J Am Dent Assoc. 2023 Jul;154(7):580-591. https://pubmed.ncbi.nlm.nih.gov/37245138/
Alkilzy M, et al. Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4. Biomimetics (Basel). 2023 Jul 4;8(3):290. https://pubmed.ncbi.nlm.nih.gov/37504178/
B K A, R Y, Puranik MP. Remineralization of early enamel caries lesions using self-assembling peptides P11-4: Systematic review and meta-analysis. J Oral Biol Craniofac Res. 2022 May-Jun;12(3):324-331. https://pubmed.ncbi.nlm.nih.gov/35433245/
Dawasaz AA, et al. Effectiveness of Self-Assembling Peptide (P11-4) in Dental Hard Tissue Conditions: A Comprehensive Review. Polymers (Basel). 2022 Feb 18;14(4):792. https://pubmed.ncbi.nlm.nih.gov/35215706/
Mohamed RN, et al. Self-assembling peptide P11-4 in remineralization of enamel caries – a systematic review of in-vitro studies. Acta Odontol Scand. 2021 Mar;79(2):139-146. https://pubmed.ncbi.nlm.nih.gov/33026894/
Arifa MK, et al. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent. 2019 Mar-Apr;12(2):139-144. https://pubmed.ncbi.nlm.nih.gov/31571787/
Philip N. State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management. Caries Res. 2019;53(3):284-295. https://pubmed.ncbi.nlm.nih.gov/30296788/
González-Cabezas C, Fernández CE. Recent Advances in Remineralization Therapies for Caries Lesions. Adv Dent Res. 2018 Feb;29(1):55-59. https://pubmed.ncbi.nlm.nih.gov/29355426/
Buzalaf MAR, Pessan JP. New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization. Monogr Oral Sci. 2017; 26:88-96. https://pubmed.ncbi.nlm.nih.gov/29050026/
Donovan TE, et al. Annual review of selected scientific literature: report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry. J Prosthet Dent. 2014 Nov;112(5):1038-87. https://pubmed.ncbi.nlm.nih.gov/25443419/
(B) Early Caries
Atteya SM, et al. Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial. BMC Oral Health. 2023 Aug 19;23(1):577. https://pubmed.ncbi.nlm.nih.gov/37598194/
Shah SV, et al. Framework for fiscal impact analysis of managing initial caries lesions with noninvasive therapies. J Am Dent Assoc. 2023 Oct;154(10):897-909. https://pubmed.ncbi.nlm.nih.gov/37770132/
Bröseler F, et al. Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries. Clin Oral Investig. 2020 Jan;24(1):123-132. https://pubmed.ncbi.nlm.nih.gov/31037343/
Doberdoli D, et al. Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Sci Rep. 2020 Mar 6;10(1):4195. https://pubmed.ncbi.nlm.nih.gov/32144336/
Schlee M, et. al. Clinical performance of self-assembling peptide P11 -4 in the treatment of initial proximal carious lesions: A practice-based case series. J Investig Clin Dent. 2018 Feb;9(1) https://pubmed.ncbi.nlm.nih.gov/28868637/
Brunton PA, et al. Treatment of early caries lesions using biomimetic self-assembling peptides-a clinical safety trial. Br Dent J. 2013 Aug;215(4) https://pubmed.ncbi.nlm.nih.gov/23969679/
Sedlakova Kondelova P, et al. Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial. Sci Rep. 2020 Nov 9;10(1):20211. https://pubmed.ncbi.nlm.nih.gov/33214593/
Deyhle H, et al. Mineralization of Early Stage Carious Lesions In Vitro-A Quantitative Approach. Dent J (Basel). 2015 Oct 10;3(4):111-122. https://pubmed.ncbi.nlm.nih.gov/29567931/
Pitts N. Summary of: Treatment of early caries lesions using biomimetic self-assembling peptides–a clinical safety trial. Br Dent J. 2013 Aug;215(4):174-5. https://pubmed.ncbi.nlm.nih.gov/23969659
(C) Orthodontic White Spot Lesions
Kobeissi R, Badr SB, Osman E. Effectiveness of Self-assembling Peptide P11-4 Compared to Tricalcium Phosphate Fluoride Varnish in Remineralization of White Spot Lesions: A Clinical Randomized Trial. Int J Clin Pediatr Dent. 2020; 13:451-456. https://pubmed.ncbi.nlm.nih.gov/33623327/
Natchiyar N, et al. Comparison of Remineralizing Agents in the Management of White Spot Lesions In Three- to Five-year-old Children: a Clinical Trial. Pediatr Dent. 2023(45):99-106. https://pubmed.ncbi.nlm.nih.gov/37106544/
Welk A, et al. Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions. Sci Rep. 2020(10):6819. https://pubmed.ncbi.nlm.nih.gov/32321955/
Ghaly YS, et al. Effect of self-assembling peptide and other remineralizing agents on preventing initial enamel lesions around orthodontic brackets: An in vitro comparative study. Int Orthod. 2023 Jun;21(2):100751. https://pubmed.ncbi.nlm.nih.gov/37003059/
(D) Regenerating/Remineralizing Properties of P11-4
Nath SJC, et al. Comparison of the Enamel Remineralisation Potential of Self-Assembling Peptides. Int Dent J. 2024 Apr;74(2):187-194. https://pubmed.ncbi.nlm.nih.gov/37743135/
Shetty SS, Nekkanti S. Remineralization Potential of a Novel Biomimetic Material (Self-assembling Peptide P11-4) on Early Enamel Caries: An In Vitro Study. J Contemp Dent Pract. 2023 Mar 1;24(3):181-187. https://pubmed.ncbi.nlm.nih.gov/37272130/
Özdemir Ş, et al. Remineralization potential of P11-4 and fluoride on secondary carious primary enamel: A quantitative evaluation using microcomputed tomography. Microsc Res Tech. 2022 Feb;85(2):807-812. https://pubmed.ncbi.nlm.nih.gov/34981866/
Üstün N, Aktören O. Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions. Microsc Res Tech. 2019 Jul;82(7):1065-1072. https://pubmed.ncbi.nlm.nih.gov/30884045/
Jablonski-Momeni A, et al. Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets. Sci Rep. 2020 Sep 15;10(1):15132. https://pubmed.ncbi.nlm.nih.gov/32934335/
Jablonski-Momeni A, et al. Efficacy of the self-assembling peptide P11-4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces. J Orofac Orthop. 2014 May;75(3):175-90. https://pubmed.ncbi.nlm.nih.gov/24825830/
Kamal D, et al. Complementary remineralizing effect of self-assembling peptide (P11-4) with CPP-ACPF or fluoride: An in vitro study. J Clin Exp Dent. 2020 Feb 1;12(2):e161-e168. https://pubmed.ncbi.nlm.nih.gov/32071698/
Üstün N, Aktören O. Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions. Microsc Res Tech. 2019 Jul;82(7):1065-1072. https://pubmed.ncbi.nlm.nih.gov/30884045
(E) In vitro studies
Barbosa-Martins LF, et al. Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents. J Mech Behav Biomed Mater. 2018;81:214-221 https://pubmed.ncbi.nlm.nih.gov/29550716/
Barbosa-Martins LF, et al. Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin. Materials (Basel). 2018; 11:1733 https://pubmed.ncbi.nlm.nih.gov/30223511/
Jablonski-Momeni A, Heinzel-Gutenbrunner M. Efficacy of the “Self-assembling peptide P11-4” in the formation of a remineralization scaffold on artificially induced enamel lesions on smooth surfaces. J Orofac Orthop 2014; 75:175-190 https://pubmed.ncbi.nlm.nih.gov/24825830/
Jablonski-Momeni A, et al. Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets. Sci Rep. 2020; 10:15132 https://pubmed.ncbi.nlm.nih.gov/32934335/
Kamal D, Hassanein H, Elkassas D, Hamza H. Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An in vitro study. J Conserv Dent. 2018;21:536-541 https://pubmed.ncbi.nlm.nih.gov/30294117/
Kamal D, Hassanein et al. Complementary remineralizing effect of self-assembling peptide (P11-4) with CPP-ACPF or fluoride: An in vitro study. J Clin Exp Dent. 2020;12:e161-e168 https://pubmed.ncbi.nlm.nih.gov/32071698/
Knaup T, Korbmacher-Steiner H, Jablonski-Momeni A. Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets. J Orofac Orthop. 2021;82:329-336. https://pubmed.ncbi.nlm.nih.gov/32876755/
Kucukyilmaz E, Savas S. Measuring the remineralization potential of different agents with quantitative light-induced fluorescence digital Biluminator. J Appl Biomater Funct Mater. 2017;15:e101-e106 https://pubmed.ncbi.nlm.nih.gov/27647387/
Moreira KM, et al. Impact of biomineralization on resin/biomineralized dentin bond longevity in a minimally invasive approach: An “in vitro” 18-month follow-up. Dent Mater. 2021;37:e276-e289. https://pubmed.ncbi.nlm.nih.gov/33608139/
Nath SJC, Fu Y, et al. A Comparison of the Enamel Remineralisation Potential of Self-Assembling Peptides. Int Dent J. 2024 Apr;74(2):187-194 https://pubmed.ncbi.nlm.nih.gov/37743135/
Özdemir Ş, Taran PK, et al. Remineralization potential of P11-4 and fluoride on secondary carious primary enamel: A quantitative evaluation using microcomputed tomography. Microsc Res Tech. 2022;85:807-812 https://pubmed.ncbi.nlm.nih.gov/34981866/
Savas S, Kucukyilmaz E, et al. Effects of Remineralization Agents on Artificial Carious Lesions. Pediatr Dent. 2016;38:511-518. https://pubmed.ncbi.nlm.nih.gov/28281957/
Schmidlin P, Zobrist K, et al. In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides. J Appl Oral Sci. 2016;24:31-6. https://pubmed.ncbi.nlm.nih.gov/27008255/
Lena Sezici Y, et al. Comparative evaluation of fluoride varnishes, self-assembling peptide-based remineralization agent, and enamel matrix protein derivative on artificial enamel remineralization in vitro. Prog Orthod. 2021 Jan 25;22(1):4. https://pubmed.ncbi.nlm.nih.gov/33491110/
Shetty SS, Nekkanti S. Remineralization Potential of a Novel Biomimetic Material (Self-assembling Peptide P11-4) on Early Enamel Caries: An In Vitro Study. J Contemp Dent Pract. 2023;24:181-187. https://pubmed.ncbi.nlm.nih.gov/37272130/
Silvertown JD, et al. Remineralization of natural early caries lesions in vitro by P11 -4 monitored with photothermal radiometry and luminescence. J Investig Clin Dent. 2017;8(4). https://pubmed.ncbi.nlm.nih.gov/28052551/
Sindhura V, Uloopi KS, et al. Evaluation of enamel remineralizing potential of self-assembling peptide P11-4 on artificially induced enamel lesions in vitro. J Indian Soc Pedod Prev Dent. 2018;36:352-356. https://pubmed.ncbi.nlm.nih.gov/30324924/
Suda S, Takamizawa T, et al. Application of the Self- Assembling Peptide P11-4 for Prevention of Acidic Erosion. Oper Dent. 2018;43:E166-E172. https://pubmed.ncbi.nlm.nih.gov/29513639/
Takahashi F, Kurokawa H, et al. Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization. Acta Odontol Scand. 2016;74:142-7. https://pubmed.ncbi.nlm.nih.gov/26156830/
Tripathi P, Mengi R, et al. Evaluation of Remineralizing Capacity of P11-4, CPP-ACP, Silver Diamine Fluoride, and NovaMin: An In Vitro Study. J Contemp Dent Pract. 2021;22:357-360. https://pubmed.ncbi.nlm.nih.gov/34267003/
Üstün N, Aktören O. Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions. Microsc Res Tech. 2019;82:1065-1072. https://pubmed.ncbi.nlm.nih.gov/30884045
SELF-ASSEMBLING PEPTIDE TECHNOLOGY
Aggeli A, et al. Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes. Nature. 1997 Mar 20;386(6622):259-62. https://pubmed.ncbi.nlm.nih.gov/9069283/
Aggeli A, et al. pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases. J Am Chem Soc. 2003 Aug 13;125(32):9619-28. https://pubmed.ncbi.nlm.nih.gov/12904028/
Camassari JR, et al. The Self-assembling peptide P11-4 influences viability and osteogenic differentiation of stem cells of the apical papilla (SCAP). J Dent. 2023 Jul;134: 104551. https://pubmed.ncbi.nlm.nih.gov/37201776/
Carvalho RG, et al. Self-assembled peptide P11-4 interacts with the type I collagen C-terminal telopeptide domain and calcium ions. Dent Mater. 2023 Aug;39(8):708. https://pubmed.ncbi.nlm.nih.gov/37394390/
Araújo IJS, et al. Self-assembly peptide P11-4 induces mineralization and cell-migration of odontoblast-like cells. J Dent. 2022; 121:104111. https://pubmed.ncbi.nlm.nih.gov/35460865/
de Souza Araújo IJ, et al. Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. Dent Mater. 2022 Nov;38(11):1749-1762. https://pubmed.ncbi.nlm.nih.gov/36180310/
Bommer C, et al. Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs. Clin Oral Investig. 2022 Mar;26(3):3151-3166. https://pubmed.ncbi.nlm.nih.gov/35006293/
Koch F, et al. Development and application of a 3D periodontal in vitro model for the evaluation of fibrillar biomaterials. BMC Oral Health. 2020; 20:148. https://pubmed.ncbi.nlm.nih.gov/32429904/
Koch F, et al. A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential. Adv Healthc Mater. 2019Jul;8(13): e1900167 https://pubmed.ncbi.nlm.nih.gov/30985084/
de Sousa JP, et al. The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin. J Dent Res. 2019 Mar;98(3):347-354. https://pubmed.ncbi.nlm.nih.gov/30612505/
Koch F, et al. Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition. R Soc Open Sci. 2018; 5:171562. https://pubmed.ncbi.nlm.nih.gov/29657766/
Kind L, et al. Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide. J Dent Res. 2017 Jul;96(7):790-797. https://pubmed.ncbi.nlm.nih.gov/28346861/
Kyle S, Aggeli A, Ingham E, McPherson MJ. Recombinant self-assembling peptides as biomaterials for tissue engineering. Biomaterials 2010;31:9395–9405. https://pubmed.ncbi.nlm.nih.gov/20932572/
Saha S, Yang XB, et al. A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study. Bone. 2019 Oct; 127:602-611. https://pubmed.ncbi.nlm.nih.gov/31351196/
Maude S, Ingham E, Aggeli A. Biomimetic self-assembling peptides as scaffolds for soft tissue engineering. Nanomedicine (Lond). 2013 May;8(5):823-47. https://pubmed.ncbi.nlm.nih.gov/23656267/
Kirkham J, Firth A, et al. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007 May;86(5):426-30. https://pubmed.ncbi.nlm.nih.gov/17452562/
Firth A, Aggeli A, et al. Biomimetic self-assembling peptides as injectable scaffolds for hard tissue engineering. Nanomedicine (Lond). 2006 Aug;1(2):189-99. https://pubmed.ncbi.nlm.nih.gov/17716108/
CURODONT PROTECT & CURODONT D’SENZ
Baltaci E, Bilmenoglu C, et al. Effect of three different remineralising agents on prevention against acidic erosion of primary teeth: an in vitro study. Eur Arch Paediatr Dent. 2023 Oct;24(5):651-659. https://pubmed.ncbi.nlm.nih.gov/37646903/
Bilge K, Kılıç V. Effects of different remineralizing agents on color stability and surface characteristics of the teeth following vital bleaching. Microsc Res Tech. 2021 Oct;84(10):2206-2218. https://pubmed.ncbi.nlm.nih.gov/33852758/
Gayas Z, Azher U, et al. Comparative Evaluation of Antimicrobial Efficacy of Fluoride-Based and Self-Assembling Peptide P11-4-based Tooth Remineralization Agents on Streptococcus mutans: A Microbiological Study. Contemp Clin Dent. 2023 Apr-Jun;14(2):141-144. https://pubmed.ncbi.nlm.nih.gov/37547429/
Ghaly YS, El-Wassefy NA, et al. Effect of self-assembling peptide and other remineralizing agents on preventing initial enamel lesions around orthodontic brackets: An in vitro comparative study. Int Orthod. 2023 Jun;21(2):100751. https://pubmed.ncbi.nlm.nih.gov/37003059/
Moras CG, Acharya SR, et al. Regenerative biomineralization potential of commercially available remineralizing agents as a preventive treatment approach for tooth erosion – An in vitro laser-induced breakdown spectroscopy analysis. J Conserv Dent. 2023 Mar-Apr;26(2):165-169 https://pubmed.ncbi.nlm.nih.gov/37205890/
Jablonski-Momeni A, Korbmacher-Steiner H, et al. Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions. Sci Rep. 2019 Jan 22;9(1):269. https://pubmed.ncbi.nlm.nih.gov/30670760/
Schlee M, Rathe F, et al. Self-assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial. J Periodontol. 2018 Jun;89(6):653-660. https://pubmed.ncbi.nlm.nih.gov/29520816/
Ardu S, Varatharaju V, et al. Protection Against Discolouration by Two Over-the Counter Desensitising Products. Oral Health Prev Dent. 2018;16(5):439-444. https://pubmed.ncbi.nlm.nih.gov/30460357/
Soares R, De Ataide IN, et al. Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study. J Clin Diagn Res. 2017 Apr;11(4):ZC136-ZC141. https://pubmed.ncbi.nlm.nih.gov/28571281/
CURODONT REPAIR & CURODONT PROTECT
Godenzi D, Bommer C, et al. Remineralizing potential of the biomimetic P11-4 self-assembling peptide on noncavitated caries lesions: A retrospective cohort study evaluating semistandardized before-and-after radiographs. J Am Dent Assoc. 2023 Oct;154(10):885-896.e9. https://pubmed.ncbi.nlm.nih.gov/37642611/
Magalhães GAP, Fraga MAA, et al. Effect of a Self-Assembly Peptide on Surface Roughness and Hardness of Bleached Enamel. J Funct Biomater. 2022 Jun 13;13(2):79. https://pubmed.ncbi.nlm.nih.gov/35735934/
Doberdoli D, Bommer C, et al. Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Sci Rep. 2020;10:4195. https://pubmed.ncbi.nlm.nih.gov/32144336/
WHITENING WITH vVARDIS TECHNOLOGY
Bommer C, Flessa HP, et al. Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening. J Clin Dent. 2018 Jun;29(2):57-63. https://pubmed.ncbi.nlm.nih.gov/30211992/
Hojabri N, Kaisarly D, et al. Adhesion and whitening effects of P11-4 self-assembling peptide and HAP suspension on bovine enamel. Clin Oral Investig. 2021 May;25(5):3237-3247. https://pubmed.ncbi.nlm.nih.gov/33108484/
Hojabri N, Kunzelmann KH. Adhesion and whitening efficacy of P11-4 self-assembling peptide and HAP suspension after using NaOCl as a pre-treatment agent. BMC Oral Health. 2022 Mar 4;22(1):59. https://pubmed.ncbi.nlm.nih.gov/35246089/
ABSTRACTS, POSTERS & PAPER PRESENTATIONS
Doberdoli D, Haliti F, Begzati A. Efficacy of Self-assembling Peptide P11-4 with Fluoride Varnish or Self-assembling Peptide Matrix for the Treatment of Early Occlusal Carious Lesions. IADR/AADR/CADR General Session 2019, Presentation 0368, Vancouver, Canada
Davies RPW, Howard R, et al. Treatment of Fabricated Caries Lesions; Self-Assembling Peptides vs Fluoride. Abstract 143. Caries Res 2015;49:359
Takahashi F, Kurokawa H, et al. Evaluation of Application of Peptide P11-4 on Remineralization of Enamel. AADR/CADR Annual Meeting, Abstract 1804, 2016, Los Angeles, USA.
Takahashi F, Suda S, Sai K, Kurokawa H, Hinoura K, Miyazaki M. Application of the Self-assembling Peptide P11-4 on Acid Erosion Prevention. IADR/AADR/CADR General Session 2017, Presentation 0375, San Francisco, USA
Patel S, Vinh A, Brubaker L, Solomon E, Amaechi B, Noureldin A. In Vitro Assessment of a Novel Biomimetic-Regeneration of Early Caries Lesions. AADR/CADR Annual Meeting 2016, Presentation 1808, Los Angeles, USA.
Brubaker L, Vinh A, Patel S, Solomon E, Amaechi B, Noureldin A. Remineralization of Early-Enamel Lesions Using Biomimetic Regeneration Combined With Fluoride-toothpaste” AADR/CADR Annual Meeting 2016, Abstract 1809, Los Angeles, USA.
Godenzi D. Give Teeth a Chance: Curodont Repair in daily practice. Lecture at EAPD, Lugano, Switzerland 2018
Brigi C. In vitro measurement of dental remineralisation: investigating a biomimetic self-assembling peptide treatment strategy. Master Thesis, Queen Mary, University of London, 2014
Burke JL. In situ engineering of skeletal tissues using self-assembled biomimetic scaffolds. PhD Thesis, University of Leeds, Leeds Dental Institute, 2011
Bienvenue à vVARDIS !
Vous êtes sur notre site pour les professionnels dentaires.
Si vous n’êtes pas un professionnel de l’art dentaire et que vous souhaitez faire un achat, veuillez consulter le site suivant vvardis.com.